1: Natural Standard (Ed). Foods, Herbs & Supplements - Quercetin, Nature Medicine Quality Standard
2: Nutrient Data Laboratory Food Composition Laboratory, U.S. Department of Agriculture. USDA Database for the Flavonoid Content of Selected Food, release 2.1, janvier 2007
3: « For his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid » Personnel de rédaction, « The Nobel Prize in Physiology or Medicine 1937 », Fondation Nobel, 2010.
4: Williams RJ, Spencer JP, Rice-Evans C (Apr 2004). « Flavonoids: antioxidants or signalling molecules? ». (review). Free Radical Biology & Medicine. 36(7): 838–849.
5: Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem. 2004;52(25):7514-7517.
6: Dok-Go H, Lee KH, Kim HJ. Neuroprotective effects of antioxidative flavonoids, quercetin,(+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten.Brain Res.2003;965(1-2):130-136.
7: Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem. 2004;52(25):7514-7517.
8: Dok-Go H, Lee KH, Kim HJ. Neuroprotective effects of antioxidative flavonoids, quercetin,(+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten.Brain Res.2003;965(1-2):130-136.
9: Patil CS, Singh VP, Satyanarayan PS, Jain NK, Singh A, Kulkarni SK. Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice. Pharmacology. 2003;69(2):59-67.
10: Williams RJ, Spencer JP, Rice-Evans C (Apr 2004). « Flavonoids: antioxidants or signalling molecules? ». (review). Free Radical Biology & Medicine. 36(7): 838–849.
11: The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Chirumbolo S1. Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85.
12: Bae SC, Jung WJ, et al. J Am Coll Nutr. 2009 Feb;28(1):56-62. Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients
13: 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects.
14: The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System. Madhavan P. Nair,* Supriya Mahajan, Jessica L. Reynolds, Ravikumar Aalinkeel, Harikrishnan Nair, Stanley A. Schwartz, and Chithan Kandaswami. Clin Vaccine Immunol. 2006 Mar; 13(3): 319–328. doi: 10.1128/CVI.13.3.319-328.2006. PMCID: PMC1391952.
15: Role of quercetin (a natural herbal compound) in allergy and inflammation. Shaik YB1, Castellani ML, Perrella A, Conti F, Salini V, Tete S, Madhappan B, Vecchiet J, De Lutiis MA, Caraffa A, Cerulli G. J Biol Regul Homeost Agents. 2006 Jul-Dec;20(3-4):47-52.
16: A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum. M. A. Johnson, R. G. Hill, and J. Hughes. Br J Pharmacol. 1988 Apr; 93(4): 932–936.
17: Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function.Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85.
18: Nutraceuticals in Prostate Disease: The Urologist’s Role. J Curtis Nickel, MD, FRCSC,* Daniel Shoskes, MD, MSc, FRCS(C),† Claus G Roehrborn, MD, FACS,‡ and Mark Moyad, MPH§. Rev Urol. 2008 Summer; 10(3): 192–206. PMCID: PMC2556486
19: Knekt P, Kumpulainen J, et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr. 2002 Sep;76(3):560-568.
20: Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. Maryam Zahedi, Reza Ghiasvand,1 Awat Feizi,2 Gholamreza Asgari,1 and Leila Darvish. Int J Prev Med. 2013 Jul; 4(7): 777–785. PMCID: PMC3775217
21: Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Egert S, Bosy-Westphal A,et al.Br J Nutr. 2009 Oct;102(7):1065-74.
22: Cardiovascular risks associated with smoking: a review for clinicians. Tonstad S1, Andrew Johnston J. Eur J Cardiovasc Prev Rehabil. 2006 Aug;13(4):507-14.
23: R. L.Edwards, T.Lyon, S.E.Litwin, A.Rabovsky, J.D.Symonset T.Jalili, « Quercetin reduces blood pressure in hypertensive subjects. »,J. Nutr.,vol. 137, 2007.
24: Perez-Vizcaino F, Duarte J, et al. Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep. 2009 Jan-Feb; 61(1):67-75.
25: Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. Maryam Zahedi, Reza Ghiasvand,1 Awat Feizi,2 Gholamreza Asgari,1 and Leila Darvish. Int J Prev Med. 2013 Jul; 4(7): 777–785. PMCID: PMC3775217
26: Yoshimoto T, Furukawa M,et al. Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase. Biochem Biophys Res Commun 1983 Oct 31;116(2):612-618.
27: Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells. Hattori M1, Mizuguchi H, Baba Y, Ono S, Nakano T, Zhang Q, Sasaki Y, Kobayashi M, Kitamura Y, Takeda N, Fukui H. Int Immunopharmacol. 2013 Feb;15(2):232-9. doi: 10.1016/j.intimp.2012.12.030. Epub 2013 Jan 16.
28: Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function.Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85.
29: Quercetin and Its Anti-Allergic Immune Response. Jiri Mlcek 1,*, Tunde Jurikova 2, Sona Skrovankova 1 and Jiri Sochor 3. Molecules 2016, 21(5), 623; doi:10.3390/molecules21050623
30: https://www.ncbi.nlm.nih.gov/pubmed/22470478
31: Meng LQ, Yang FY, Wang MS, Shi BK, Chen DX, Chen D, Zhou Q, He QB, Ma LX, Cheng WL, Xing NZ. Quercetin protects against chronic prostatitis in rat model through NF-κB and MAPK signaling pathways. PMID: 29654614. DOI: 10.1002/pros.23536
32: Shoskes DA, Zeitlin SI, et al. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999 Dec; 54(6):960-963.
33: Nutraceuticals in Prostate Disease: The Urologist’s Role. J Curtis Nickel, MD, FRCSC,* Daniel Shoskes, MD, MSc, FRCS(C),† Claus G Roehrborn, MD, FACS,‡ and Mark Moyad, MPH§. Rev Urol. 2008 Summer; 10(3): 192–206. PMCID: PMC2556486
34: Shoskes DA, Zeitlin SI, et al. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999 Dec; 54(6):960-963.
35: Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation:
36: Vrolijk MF et al. The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation. European Journal of Pharmacology 2015 Jan 5; 746:132-37
37: Katske F, Shoskes DA, et al. Treatment of interstitial cystitis with a quercetin supplement. Tech Urol. 2001 Mar;7(1):44-6.
38: Flavonols and pancreatic cancer risk: the multiethnic cohort study. Nöthlings U, Murphy P, et al. Am J Epidemiol. 2007 Oct 15;166(8):924-931.
39: « Flavonoid intake and risk of pancreatic cancer in male smokers » (Finland). Bobe G, Weinstein SJ,et al.Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):553-62.
40: Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin Shekoufeh Atashpour,1 Shamileh Fouladdel,1 Tahereh Komeili Movahhed,2 Elmira Barzegar,1 Mohammad Hossein Ghahremani,3 Seyed Nasser Ostad,3 and Ebrahim Azizi1. Iran J Basic Med Sci. 2015 Jul; 18(7): 635–643. PMCID: PMC4556754
41: Hormesis and synergy: pathwaysand mechanisms of quercetin in cancer prevention and management. Vargas AJ, Burd R.Nutr Rev. 2010 Jul;68(7):418-428.
42: Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis. Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary, Sathees C. Raghavan. doi:10.1038/srep24049
43: Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway. Xiang-An Zhang, Shuangxi Zhang, Qing Yin,1 and Jing Zhang. Pharmacogn Mag. 2015 Apr-Jun; 11(42): 404–409. doi: 10.4103/0973-1296.153096
44: Ashley B. Ward, Hina Mir, Neeraj Kapur, Dominique N. Gales, Patrick P. Carriere, and Shailesh Singh. Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways. World J Surg Oncol 2018. doi: 10.1186/s12957-018-1400-z. PMCID: PMC6001031. PMID: 2989873
45: Moutsatsou P (2007). « The spectrum of phytoestrogens in nature: our knowledge is expanding ». (review). Hormones (Athens, Greece). 6(3): 173–193
46: Maggiolini M, Vivacqua A, Fasanella G, Recchia AG, Sisci D, Pezzi V, Montanaro D, Musti AM, Picard D, Andò S (2004). « The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17 beta-estradiol and phytoestrogens in breast cancer cells ». (primary).The Journal of Biological Chemistry. 279(26): 27008–27016.
47: Prossnitz ER, Barton M (May 2014). « Estrogen biology: new insights into GPER function and clinical opportunities ».Molecular and Cellular Endocrinology. 389(1-2): 71–83.
48: https://www.uofmhealth.org/health-library/hn-1015003
49: https://www.ncbi.nlm.nih.gov/pubmed/21606866
50: Formica JV, Regelson W (1995). « Review of the biology of Quercetin and related bioflavonoids
51: « For his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid » Personnel de rédaction, « The Nobel Prize in Physiology or Medicine 1937 », Fondation Nobel, 2010.
52: [13] Giuliani C, Bucci I, Di Santo S, et al, The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function, Food and Chemical Toxicology, 2014;66:23-29
53: Choi et al, Comparative Effect of Quercetin and Quercetin-3-O-β-d-Glucoside on Fibrin Polymers, Blood Clots, and in Rodent Models. J Biochem Mol Toxicol. 2016 Nov;30(11):548-558. doi: 10.1002/jbt.21822. Epub 2016 Jun 7.
54: Effect of quercetin on the pharmacokinetics of oral cyclosporine. Choi JS, Choi BC, Choi KE. Am J Health Syst Pharm. 2004 Nov 15;61(22):2406.
55: Hilliard JJ, Krause HM, Bernstein JI, Fernandez JA, Nguyen V, Ohemeng KA, Barrett JF (1995). « A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase ». Advances in Experimental Medicine and Biology. 390: 59–69.
56: Bun SS, Ciccolini J, Bun H, AubertC, Catalin J (Jun 2003). « Drug interactions of paclitaxel metabolism in human liver microsomes ». Journal of Chemotherapy. 15(3): 266–274.
57: Données établies par le Département de l’Agriculture des États-Unis, « USDA Database for the Flavonoid Content of Selected Foods ».
58: Smith C, Lombard KA, Peffley EB, Liu W (2003). « Genetic Analysis of Quercetin in Onion (Allium cepa L.) Lady Raider ». The Texas Journal of Agriculture and Natural Resource. Agriculture Consortium of Texas. 16: 24–28.
59: Formica JV, Regelson W (1995). « Review of the biology of Quercetin and related bioflavonoids ». Food and Chemical Toxicology. 33(12): 1061–1080.